The article reviews the variability in radiologic oncology assessments, particularly focusing on RECIST 1.1 criteria, which standardize evaluations to improve consistency and accuracy. It discusses how variability arises from factors like radiologist expertise, image quality, and lesion selection, and emphasizes the importance of standardized protocols and training to mitigate these issues. By addressing the root causes of variability, the article aims to enhance the precision of response assessments, ultimately leading to better patient care and clinical outcomes.